Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592738 | Bioorganic & Medicinal Chemistry Letters | 2014 | 7 Pages |
Abstract
A new class of imine derivatives of hybrid chalcone analogues containing anthraquinone scaffold was synthesized and evaluated for their in vitro cytotoxic activity against HeLa, LS174, and A549 cancer cells. The compound 5n with furan ring linked to imino group showed potent activity against all target cells with IC50 values ranging from 1.76 to 6.11 μM. A mode of action study suggested that compounds induced changes typical for apoptosis in HeLa cells. The most active compounds inhibited tubulogenesis and 5h was found to exhibit a strong anti-angiogenic effect.
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Authors
Branka Kolundžija, Violeta MarkoviÄ, Tatjana StanojkoviÄ, Ljubinka JoksoviÄ, Ivana MatiÄ, Nina TodoroviÄ, Marijana NikoliÄ, Milan D. JoksoviÄ,