| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592745 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
An highly quaternary and unprecedented dispiro compound, verrulactone C (1), with the known compound, altenuisol (2), were isolated from a culture broth of the fungal strain Penicillium verruculosum F375. Verrulactone C and altenuisol showed FabI-selective inhibition. Especially, altenuisol had the high correlation between FabI-inhibition and whole cell antibacterial activity against S. aureus and MRSA with MICs of 8-32 μg/mL.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nyung Kim, Mi-Jin Sohn, Hiroyuki Koshino, Eun-Hee Kim, Won-Gon Kim,