| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592761 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Isoxazole-1,4-dihydropyridines (IDHPs) were tethered to fluorescent moieties using double activation via a lanthanide assisted Weinreb amidation. IDHP-fluorophore conjugate 3c exhibits the highest binding to date for IDHPs at the multidrug-resistance transporter (MDR-1), and IDHP-fluorophore conjugates 3c and 7 distribute selectively in SH-SY5Y cells. A homology model for IDHP binding at hMDR-1 is presented which represents our current working hypothesis.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Monika I. Szabon-Watola, Sarah V. Ulatowski, Kathleen M. George, Christina D. Hayes, Scott A. Steiger, Nicholas R. Natale,