| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592786 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tenna Juul Schrøder, Søren Christensen, Samsa Lindberg, Morten Langgård, Laurent David, Philip J. Maltas, Jørgen Eskildsen, Jan Jacobsen, Lena Tagmose, Klaus Bæk Simonsen, Lars Christian Biilmann Rønn, Inge E.M. de Jong, Ibrahim J. Malik,