Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592814 | Bioorganic & Medicinal Chemistry Letters | 2014 | 11 Pages |
Abstract
A novel series of 2-(5-methyl-1,3-diphenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazoles 7(a-m) were synthesized either by cyclization of Nâ²-benzoyl-5-methyl-1,3-diphenyl-1H-pyrazole-4-carbohydrazide 4a using POCl3 at 120 °C or by oxidative cyclization of hydrazones derived from various arylaldehyde and (E)-Nâ²-benzylidene-5-methyl-1,3-diphenyl-1H-pyrazole-4-carbohydrazide 5(a-d) using chloramine-T as oxidant. Newly synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, 13C NMR and LC-MS) methods. The synthesized compounds were evaluated for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Among the synthesized compounds, compound 7m emerged as an effective antimicrobial agent, while compounds 7d, 7f, 7i and 7l showed good to moderate activity. The minimum inhibitory concentration of the compounds was in the range of 20-50 μg mLâ1 against bacteria and 25-55 μg mLâ1 against fungi. The title compounds represent a novel class of potent antimicrobial agents.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Srikantamurthy Ningaiah, Umesha K. Bhadraiah, Shridevi D. Doddaramappa, Shubakara Keshavamurthy, Chethan Javarasetty,