Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592837 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Detection of DNA damage has been greatly improved following the development of equipment and techniques, however, discrimination between 5-hydroxymethylcytosine (5-hmC) and 5-methylcytosine (5-mC) is still a thorny problem. In the present study, an approach to oxidize and selective label (Ox-Labeling) 5-hmC in native DNA has been reported, which conveniently distinguishes 5-hmC from 5-mC using simple and effective processes.
Related Topics
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Authors
Jianlin Hu, Yuqi Chen, Xiaowei Xu, Fan Wu, Xiwen Xing, Zhenghao Xu, Jiahui Xu, Xiaocheng Weng, Xiang Zhou,