| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592838 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A novel series of 1,2,4-triazino-[5,6b]indole-3-thione covalently linked to 7-chloro-4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular amastigote form of Leishmania donovani. Among all tested compounds, compounds 7a and 7b were found to be the most active with IC50 values 1.11, 0.36 μM and selectivity index (SI) values 67, >1111, respectively, against amastigote form of L. donovani which is several folds more potent than the standard drugs, miltefosine (IC50 = 8.10 μM, SI = 7) and sodium stibo-gluconate (IC50 = 54.60 μM, SI ⩾ 7).
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Authors
Rashmi Sharma, Anand Kumar Pandey, Rahul Shivahare, Khushboo Srivastava, Suman Gupta, Prem M.S. Chauhan,