Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592862 | Bioorganic & Medicinal Chemistry Letters | 2014 | 7 Pages |
Abstract
In an attempt to identify novel inhibitors of NAD+-dependent DNA ligase (LigA) that are not affected by a known resistance mutation, a detailed analysis of the binding sites of a variety of bacterial ligases was performed. This analysis revealed several similarities to the adenine binding region of kinases, which enabled a virtual screen of known kinase inhibitors. From this screen, a thienopyridine scaffold was identified that was shown to inhibit bacterial ligase.
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Authors
Kerry Murphy-Benenato, Hongming Wang, Helen M. McGuire, Hajnalka E. Davis, Ning Gao, D. Bryan Prince, Haris Jahic, Suzanne S. Stokes, P. Ann Boriack-Sjodin,