Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592867 | Bioorganic & Medicinal Chemistry Letters | 2014 | 7 Pages |
Abstract
A number of delivery agents, such as proteins, liposomes, micelles, and nanoparticles, are utilized for transporting pharmaceutical agents in a physiological environment. This Letter focuses on the use of the copper(II) ion and its potential role as a delivery agent for the taxanes and taxol couple to a malaria drug. Nuclear magnetic resonance (NMR, 1H, 13C, 15N), Mass Spectrometry (LC-MS, MALDI-TOF, FT-ICR) and computational methods are used to examine the structure of the complex. The National Cancer Institute's benchmark 60 cell line panel is used to compare the efficacy of the copper-taxol and copper-taxol-hydroxychloroquin complexes to that of iron-taxol and pure taxol.
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Authors
Thomas J. Manning, Dennis Phillips, Greg Wylie, Benjamin Bythell, Shannon Clark, Ryenne Ogburn, Kaitlyn Ledwitch, Chad Collis, Stephanie Patterson, Landon Lasseter,