| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592869 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
The design, synthesis, and SAR of cyclic diamines as novel γ secretase modulators (GSMs) are presented in this Letter. Starting from information in the literature and in-house cyclic diamines library, we have found a 3(S)-aminopiperidine as a potent structure for lowering Aβ42 production both in vitro and in vivo.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tomonori Kobayashi, Seiji Iwama, Akira Fusano, Yoshihiro Kato, Atsushi Ikeda, Yasuhiro Teranishi, Akemi Nishihara, Masanori Tobe,