| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592896 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.
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Authors
Bhushan Shakya, Paras Nath Yadav, Jun-ya Ueda, Suresh Awale,