Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592956 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
In order to develop new drugs for Alzheimer's disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4Z,15Z)-octadecadienoic acid (10) and (23Z,34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on Aβ(25-35)-treated rat cortical neurons, which activities were comparable to that of a positive control, NGF. Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hong-Yan Zhang, Yu-ichiro Yamakawa, Yuji Matsuya, Naoki Toyooka, Chihiro Tohda, Suresh Awale, Feng Li, Shigetoshi Kadota, Yasuhiro Tezuka,