| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592968 | Bioorganic & Medicinal Chemistry Letters | 2014 | 8 Pages |
Abstract
We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yang Yang, Yun He, Xingzhe Li, Hieu Dinh, Suri S. Iyer,