Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10592980 | Bioorganic & Medicinal Chemistry Letters | 2014 | 8 Pages |
Abstract
The design and synthesis of a series of substituted heteroaromatic α4β2α5 positive allosteric modulators is reported. The optimization and development of the heteroaromatic series was carried out from NS9283, and several potent analogues, such as 3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile (5k) and 3,3â²-(2H-tetrazole-2,5-diyl)dipyridine (12h) with good in vitro efficacy were discovered.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhuang Jin, Pasha Khan, Youseung Shin, Jingyi Wang, Li Lin, Michael D. Cameron, Jon M. Lindstrom, Paul J. Kenny, Theodore M. Kamenecka,