| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10592996 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A series of dipeptide derivatives of l-dopa were synthesized and investigated for their pharmacological activity using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat as an experimental model of Parkinson's disease. Among them, (S)-isopropyl 2-(2-amino-2-methylpropanamido)-3-(3,4-dihydroxyphenyl)propanoate (4g) was found to be the most active compound, with 106% AUC activity and 149% peak activity of l-dopa after oral administration.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tao Zhou, Robert C. Hider, Peter Jenner, Bruce Campbell, Christopher J. Hobbs, Sarah Rose, Mark Jairaj, Kayhan A. Tayarani-Binazir, Alexander Syme,