Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593070 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A series of class A compounds which have the basic skeleton of ABT-737 and the h2 residues of Bim BH3 were designed, and showed broad-spectrum binding activity to target proteins similar to that of Bim BH3 peptide. Then class B compounds were synthesized by modifying the structure of the most effective class A compound, A-4, and showed better binding affinity to the target proteins.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Can-Hui Zheng, Hui Yang, Meng Zhang, Shi-Hai Lu, Duo Shi, Juan Wang, Xiu-Hua Chen, Xiao-Hui Ren, Jia Liu, Jia-Guo Lv, Ju Zhu, You-Jun Zhou,