Article ID Journal Published Year Pages File Type
10593070 Bioorganic & Medicinal Chemistry Letters 2012 6 Pages PDF
Abstract
A series of class A compounds which have the basic skeleton of ABT-737 and the h2 residues of Bim BH3 were designed, and showed broad-spectrum binding activity to target proteins similar to that of Bim BH3 peptide. Then class B compounds were synthesized by modifying the structure of the most effective class A compound, A-4, and showed better binding affinity to the target proteins.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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