Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593099 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the synthesised target sequences, probe-target duplex formation could lead to enhanced or attenuated fluorescence emission from the anthracene, enabling detection of a proximal base-pair as either matching or mismatching.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zheng-yun Zhao, Marie San, Jean-Louis H.A. Duprey, John R. Arrand, Joseph S. Vyle, James H.R. Tucker,