| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593143 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of pyrazoloquinoline analogs have been synthesized and shown to bind to PDE10 with high affinity. From the SAR study and our lead optimization efforts, compound 27 was found to possess potent oral antipsychotic activity in the MK-801 induced hyperactive rat model.
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Authors
Shu-Wei Yang, Jennifer Smotryski, William T. McElroy, Zheng Tan, Ginny Ho, Deen Tulshian, William J. Greenlee, Mario Guzzi, Xiaoping Zhang, Deborra Mullins, Li Xiao, Alan Hruza, Tze-Ming Chan, Diane Rindgen, Carina Bleickardt, Robert Hodgson,