Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593159 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
Directed screening has identified a novel series of non-zinc binding MMP13 inhibitors that possess good levels of activity whilst demonstrating excellent selectivity over related MMPs. A lead optimisation campaign has delivered compounds with enhanced MMP13 potency, good selectivity and acceptable bioavailability profiles leading to a predicted twice-a-day dosing regimen in man.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chris De Savi, Andrew D. Morley, Ian Nash, Galith Karoutchi, Ken Page, Attilla Ting, Stefan Gerhardt,