| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593175 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The synthesis of 5-alkyl pyrimidine derivatives, 5,6-dihydrofuro[2,3-d]pyrimidines and 5-alkyl N-methoxymethyl pyrimidine derivatives and their cytostatic evaluation are described. The mechanism of antiproliferative effect and ADME profile of 5-(2-chloroethyl)-substituted pyrimidine 3 that exerted the most pronounced cytostatic activity are also reported.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tatjana Gazivoda KraljeviÄ, Mateja Klika, Marijeta Kralj, Irena Martin-Kleiner, Stella JurmanoviÄ, Astrid MiliÄ, Jasna Padovan, Silvana RaiÄ-MaliÄ,