Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593179 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
[18F]-labeled molecular probe for the detection of myocardial perfusion deficit is driving particular interest due to its high clinical applicability. Thus, we synthesized (2-(2-[18F]fluoroethoxy)ethyl)triphenylphosphonium salt ([18F]3) that specifically accumulates in myocardium according to mitochondrial membrane potential. Here, we evaluated the performance of [18F]3 as a mitochondrial voltage sensor in vitro and in vivo. The [18F]3 was synthesized with 20â¼30% radiochemical yield and radiochemical purity was >98% by analytical HPLC. Specific activity was >6.7 TBq/μmol. The cellular uptake assay showed preferential uptake of [18F]3 in cardiomyocytes. The results of biodistribution and micro-PET imaging studies of [18F]3 in mice and rats showed preferential accumulation in the myocardium. The results suggest that this compound would be a promising candidate for myocardial imaging.
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Authors
Dong-Yeon Kim, Hee-Jung Kim, Kook-Hyun Yu, Jung-Joon Min,