| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593194 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
We previously reported CXCR3 clinical candidate compound, AMG 487. This Letter reported the efforts to discover the second generation of CXCR3 antagonist. From these efforts, compounds 25 is a much potent analog than AMG 487 with excellent bioavailability in multiple preclinical species and demonstrated efficacy in a mouse model of bleomycin-induced leukocytes trafficking into the lung.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaoqi Chen, Jeff Mihalic, Jeff Deignan, Darin J. Gustin, Jason Duquette, Xiaohui Du, Johann Chan, Zice Fu, Michael Johnson, An-Rong Li, Kirk Henne, Tim Sullivan, Bryan Lemon, Ji Ma, Shichang Miao, George Tonn, Tassie Collins, Julio C. Medina,