Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593198 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
We have previously reported that optimization of a series of phenylacetic acid derivatives led to the discovery of CRTH2 and DP dual antagonists, such as AMG 009 and AMG 853. During the optimization process, we discovered that minor structural modifications also afforded potent and selective CRTH2 or DP antagonists. Here we report the structure-activity relationship that led to the discovery of selective CRTH2 antagonists such as 2 and 17, and selective DP antagonists, such as 4 and 5.
Related Topics
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Organic Chemistry
Authors
Yingcai Wang, Zice Fu, Michael Schmitt, Xuemei Wang, Wang Shen, Erika Rickel, Tod Martin, Alison Budelsky, Derek Marshall, Tassie Collins, H. Lucy Tang, Julio C. Medina, Jiwen (Jim) Liu,