Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593229 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas were designed, synthesized and tested. In addition to the native turn residues, the cyclic peptides include a linker unit between the N- and C-termini, selected by molecular modeling among various non-proteinogenic cyclic amino acids. NMR conformational studies showed that most of the cyclic peptides were able to adopt turn-like structures. Several of the analogues displayed significant inhibition of the BDNF-induced TrkB receptor phosphorylation, and hence could be useful templates for developing improved antagonists for this receptor.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
José Luis Baeza, Beatriz G. de la Torre, Clara M. Santiveri, Ramiro D. Almeida, M. Teresa GarcÃa-López, Guillermo Gerona-Navarro, Samie R. Jaffrey, M. Ángeles Jiménez, David Andreu, Rosario González-Muñiz, Mercedes MartÃn-MartÃnez,