| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593244 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A number of novel fused thiophene derivatives have been prepared and identified as potent inhibitors of MEK. The SAR data of selected examples and the in vivo profiling of compound 13h demonstrates the functional activity of this class of compounds in HT-29 PK/PD models.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Victoria E. Laing, Daniel C. Brookings, Rachel J. Carbery, Jose Gascon Simorte, Martin C. Hutchings, Barry J. Langham, Martin A. Lowe, Rodger A. Allen, Joanne R. Fetterman, James Turner, Christoph Meier, Jeff Kennedy, Mark Merriman,