| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593264 | Bioorganic & Medicinal Chemistry Letters | 2013 | 8 Pages |
Abstract
We describe a medicinal chemistry approach for generating a series of 2-(1H-pyrazol-1-yl)thiazoles as EP1 receptor antagonists. To improve the physicochemical properties of compound 1, we investigated its structure-activity relationships (SAR). Optimization of this lead compound provided small compound 25 which exhibited the best EP1 receptor antagonist activity and a good SAR profile.
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Authors
Masakazu Atobe, Kenji Naganuma, Masashi Kawanishi, Akifumi Morimoto, Ken-ichi Kasahara, Shigeki Ohashi, Hiroko Suzuki, Takahiko Hayashi, Shiro Miyoshi,