| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593332 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A new series of urea-based, 4-bicyclic heteroaryl-piperidine derivatives as potent SCD1 inhibitors is described. The structure-activity relationships focused on bicyclic heteroarenes and aminothiazole-urea portions are discussed. A trend of dose-dependent decrease in body weight gain in diet-induced obese (DIO) mice is also demonstrated.
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Authors
Shyh-Ming Yang, Yuting Tang, Rui Zhang, Huajun Lu, Gee-Hong Kuo, Michael D. Gaul, Yaxin Li, George Ho, James G. Conway, Yin Liang, James M. Lenhard, Keith T. Demarest, William V. Murray,