Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593339 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Targeting viral polymerases has been a proven and attractive strategy for antiviral drug discovery. Herein we describe our effort in improving the antiviral activity and physical properties of a series of benzothienoazepine compounds as respiratory syncytial virus (RSV) RNA polymerase inhibitors. The antiviral activity and spectrum of this class was significantly improved by exploring the amino substitution of the pyridine ring, resulting in the discovery of the most potent RSV A polymerase inhibitors reported to date.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hui Xiong, Melinda Foulk, Lisa Aschenbrenner, Jun Fan, Choi-Lai Tiong-Yip, Kenneth D. Johnson, Demetri Moustakas, Paul R. Fleming, Dean G. Brown, Minli Zhang, Douglas Ferguson, Dedong Wu, Qin Yu,