| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593404 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
The discovery of a series of 6-(4-pyridyl)pyrimidin-4(3H)-ones derived from a hit compound with low molecular weight and sufficient chemical space is reported. Transformation of substituents led to subnanomolar potent inhibitors with in vivo tau phoshorylation lowering activity.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fumiaki Uehara, Aya Shoda, Keiichi Aritomo, Kenji Fukunaga, Kazutoshi Watanabe, Ryoichi Ando, Masaki Shinoda, Hiroaki Ueno, Hideo Kubodera, Shinji Sunada, Ken-Ichi Saito, Takahide Kaji, Shoichi Asano, Jun-ichi Eguchi, Satoshi Yuki, Shinji Tanaka,