Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593424 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Through scaffold morphing of a known Smoothened antagonist Antag691, a series of novel phenyl imidazole derivatives were developed. Structure-activity-relationship studies and lead optimization led to the discovery of potent, selective and orally bioavailable Smoothened antagonist 19 that is suitable for in vivo studies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dai Cheng, Dong Han, Wenqi Gao, Qihui Jing, Jiqing Jiang, Yongqin Wan, Nathan P. Englund, Tove Tuntland, Xu Wu, Shifeng Pan,