Article ID Journal Published Year Pages File Type
10593424 Bioorganic & Medicinal Chemistry Letters 2012 4 Pages PDF
Abstract
Through scaffold morphing of a known Smoothened antagonist Antag691, a series of novel phenyl imidazole derivatives were developed. Structure-activity-relationship studies and lead optimization led to the discovery of potent, selective and orally bioavailable Smoothened antagonist 19 that is suitable for in vivo studies.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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