| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593429 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of potential DFMO prodrugs was designed through the incorporation of 4-nitrobenzyl ester or carbamate groups for potential activation by trypanosomal nitroreductase. It was found that only modification of Nε-amino group of DFMO by 4-nitro-2-fluorobenzyloxycarbonyl resulted in significant trypanocidal activity and could serve as a lead for further investigation.
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Authors
Yanhui Yang, Andrew Voak, Shane R. Wilkinson, Longqin Hu,