| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593435 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Based on in silico screening results, a series of novel 3,5-diarylpyrazoline salicylamide derivatives were designed and synthesized. Compound 25 exhibited the most potent inhibitory activity with an IC50 value of 0.16 μM for BRAFV600E and GI50 value of 0.24 μM for mutant BRAF-dependent WM266.4 melanoma cells.
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Authors
Qing-Shan Li, Xian-Hai Lv, Yan-Bin Zhang, Jing-Jun Dong, Wen-Ping Zhou, Yang Yang, Hai-Liang Zhu,