| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593450 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Betty Lam, Zhiyuan Zhang, Jeffery A. Stafford, Robert J. Skene, Lihong Shi, Stephen L. II,