| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593462 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Based on a favorable balance between CRF-R1 affinity, lipophilicity and metabolic stability, compound 10 was evaluated for potential development as PET radioligand. Compound [18F]10 was prepared with high radiochemical purity and showed promising binding properties in rat brain imaging experiments.
Keywords
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Organic Chemistry
-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: Introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents](/preview/png/10593462.png "First Page Preview: [18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: Introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents")
Authors
Jeffrey A. Deskus, Douglas D. Dischino, Ronald J. Mattson, Jonathan L. Ditta, Michael F. Parker, Derek J. Denhart, Dmitry Zuev, Hong Huang, Richard A. Hartz, Vijay T. Ahuja, Henry Wong, Gail K. Mattson, Thaddeus F. Molski, James E. Jr., Larisa Zueva,