Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593482 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ash Bahl, Patrick Barton, Keith Bowers, Moya V. Caffrey, Rebecca Denton, Peter Gilmour, Shaun Hawley, Tero Linannen, Christopher A. Luckhurst, Tobias Mochel, Matthew W.D. Perry, Robert J. Riley, Emma Roe, Brian Springthorpe, Linda Stein, Peter Webborn,