Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593492 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Advanced glycation end-products, namely AGEs, are involved in the pathogenesis of numerous diseases. If AGEs inhibitors are well-known, only few products are described as compounds able to destroy those deleterious products. In this work, we describe naphthoic acid derivatives, particularly 1-(naphthalen-1-yl)propane-1,2-dione 9, allowing the simple and rapid detection of AGEs breakers using a 96-well microplate fluorescence assay. Since the inaugurate publication about AGEs breakers whose activity was demonstrated using HPLC analysis, this work proposes the first assay suitable for automated and high throughput screening of AGEs breakers.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Luc Séro, François Calard, Lionel Sanguinet, Eric Levillain, Pascal Richomme, Denis Séraphin, Séverine Derbré,