| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593525 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
We synthesized stapled helical leucine-based peptides (DPI-01-07) containing 2-aminoisobutyric acid and a covalent cross-linked unit as inhibitors of vitamin D receptor (VDR)-coactivator interactions. The effects of these peptides on the human VDR were examined in an inhibition assay based on the receptor cofactor assay system, and one of them, DPI-07, exhibited potent inhibitory activity (IC50: 3.2 μM).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yosuke Demizu, Saori Nagoya, Manami Shirakawa, Megumi Kawamura, Nanako Yamagata, Yukiko Sato, Mitsunobu Doi, Masaaki Kurihara,