| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593543 | Bioorganic & Medicinal Chemistry Letters | 2013 | 17 Pages |
Abstract
A series of structurally novel mono-carbonyl curcumin analogues have been synthesized and biologically evaluated to test their inhibitory potencies and the structure-activity relationship (SAR) on human and rat 11β-hydroxysteroid dehydrogenase isoform (11β-HSD1) activities. 11β-HSD1 selective inhibitors have been discovered and compound A10 is discovered as a very potent with an IC50 value of 97 nM without inhibiting 11β-HSD2.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Han Lin, Guo-Xin Hu, Jingjing Guo, Yufei Ge, Guang Liang, Qing-Quan Lian, Yanhui Chu, Xiaohuan Yuan, Ping Huang, Ren-Shan Ge,