| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593548 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A series of potent α4β1/α4β7 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of rheumatoid arthritis and Crohn's disease.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ying-zi Xu, Jenifer L. Smith, Christopher M. Semko, Kassandra I. Rossiter, Juri Y. Fukuda, Michael S. Dappen, David A. Quincy, Andrei W. Konradi, Wenxian Mao, Brent Welch, Mark L. Dreyer, Bhushan Samant, Hongbin Zhang, Judevin Lugar, Zhenmei Liao,