| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593728 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of fused bicyclic heterocycles was identified as potent and selective 5-HT2A receptor antagonists. Optimization of the series resulted in compounds that had improved PK properties, favorable CNS partitioning, good pharmacokinetic properties, and significant improvements on deep sleep (delta power) and sleep consolidation.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, Martin Cherrier, Sonja Strah-Pleynet, Marc Decaire, Konrad Feichtinger, John M. Frazer, Woo H. Yoon, Kevin Whelan, Erin K. Sanabria, Andrew J. Grottick, Hussien Al-Shamma, Graeme Semple,