| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593740 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy in the rat chronic constriction injury (CCI)-induced model of neuropathic pain is described.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raul R. Calvo, Sanath K. Meegalla, Daniel J. Parks, William H. Parsons, Shelley K. Ballentine, Mary Lou Lubin, Craig Schneider, Raymond W. Colburn, Christopher M. Flores, Mark R. Player,