| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593744 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Sulfide and sulfonyl derivatives of 1,2,4-oxadiazoles were synthesized and screened by MTT assay on the prostate cancer cells, DU-145. Six compounds were identified as potential anti-prostate cancer agents with IC50 values ranging from 0.5 to 5.1 μM. These compounds exhibited good activity on the androgen independent cells PC-3, while the results were moderate on androgen dependent LNCaP cells, suggesting the possibility of a mechanism of action different from that of the bioisosteric bicalutamide. Also a very low cytotoxicity was observed on non-cancerous cells MCF-10A.
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Authors
Gopal L. Khatik, Jasmine Kaur, Varun Kumar, Kulbhushan Tikoo, Vipin A. Nair,