| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593750 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
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Authors
L. Guandalini, E. Martini, L. Di Cesare Mannelli, S. Dei, D. Manetti, S. Scapecchi, E. Teodori, C. Ghelardini, M.N. Romanelli,