| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593754 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (Ki) less than 1Â nM. Kinase selectivity is reasonable and cytotoxicity corresponds to inhibition of MCM2 phosphorylation.
Related Topics
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Organic Chemistry
Authors
Keith W. Woods, Chunqiu Lai, Julie M. Miyashiro, Yunsong Tong, Alan S. Florjancic, Edward K. Han, Niru Soni, Yan Shi, Loren Lasko, Joel D. Leverson, Eric F. Johnson, Alexander R. Shoemaker, Thomas D. Penning,