| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593755 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.
Related Topics
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Chemistry
Organic Chemistry
Authors
Udo Bauer, Fabrizio Giordanetto, Martin Bauer, Gavin O'Mahony, Kjell E. Johansson, Wolfgang Knecht, Judith Hartleib-Geschwindner, Eva Töppner Carlsson, Cristofer Enroth,