Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593789 | Bioorganic & Medicinal Chemistry Letters | 2014 | 7 Pages |
Abstract
Novel series of 1-(arenesulfonyl)imidazolidin-2-one (3a-i) and 1,3-bis(arenesulfonyl)imidazolidin-2-one (5a-i) have been synthesized and tested for their antitumor activity against 60 tumor cell lines taken from nine different organs. A significant inhibition for cancer cells was observed with series 5a-i compounds compared with the series 3a-i which showed a weak inhibition. Compounds 5a-i showed good inhibitory effect at the lung cancer HOP-92 and renal cancer CAKI-1 and UO-31 cell lines. Compound 5e showed remarkable broad-spectrum antitumor activity.
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Authors
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Hussein I. El-Subbagh, Abdulrahman M. Al-Obaid, Amer M. Alanazi, Mohamed A. Al-Omar,