| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593794 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
We report a hit to lead study on a novel benzoxazole NPY Y5 antagonist. Starting from HTS hit 1, structure-activity relationships were developed. Compound 12 showed reduction of food intake and a tendency to suppress body weight gain over the 21-day experimental period.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Naoki Omori, Naoki Kouyama, Akira Yukimasa, Kana Watanabe, Yasunori Yokota, Hideki Tanioka, Hirohide Nambu, Hideo Yukioka, Norihito Sato, Yukari Tanaka, Kazutaka Sekiguchi, Takayuki Okuno,