Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10593829 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A new series of polyhydroxylated N-benzylbenzamide derivatives containing an adamantyl moiety has been synthesized, and the depigmenting and tyrosinase inhibitory activities of the molecules were evaluated. The lipophilic character of the adamantyl moiety appeared to confer greater depigmentation power on the benzamide derivatives as compared to those lacking adamantyl substitution. Molecular modeling was applied in order to elucidate the interactions between ligands and tyrosinase that led to inhibition.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Heung Soo Baek, Yong Deog Hong, Chang Seok Lee, Ho Sik Rho, Song Seok Shin, Young-Ho Park, Yung Hyup Joo,