| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593830 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis ROLFE, we found phoyunbene B (PYB, trans-3,4â²-dihydroxy-2â²,3â²,5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Guanghui Wang, Xiaoyu Guo, Haifeng Chen, Ting Lin, Yang Xu, Quancheng Chen, Jie Liu, Jinzhang Zeng, Xiao-kun Zhang, Xinsheng Yao,