| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593987 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
Through the analysis of X-ray crystallographic information and previous SAR studies, a novel series of protein kinase B (PKB/AKT) inhibitors was developed. The compounds showed nanomolar inhibition of AKT1 and were selective against cyclin-dependent kinase 2 (CDK2).
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Authors
Kate S. Ashton, David J. Jr., Steve F. Poon, Matthew R. Lee, John G. Allen, Shiwen Zhang, Julie A. Lofgren, Xiaoling Zhang, Christopher Fotsch, Randall Hungate,